In vitro approach to study the influence of the cardiac output distribution on drug concentration

Dublin Core

Título

In vitro approach to study the influence of the cardiac output distribution on drug concentration

Tema

CARDIOLOGIA
SANGRE
SISTEMA CARDIOVASCULAR
PRODUCTOS FARMACEUTICOS
BIBLIOGRAFIA NACIONAL QUIMICA

Abstract

Blood flow is not constant during the day, not only due to cardiac output variation but to the variable blood flow fraction supplied to the organs. To what extent these variations could affect the relative drug concentration between two different tissues, is the purpose of this work. In order to study that, a device was designed which took into account different fluid flows towards two flasks. Connections between flasks and pump are shown in text (figure 1). At the bottom of each flask a non-miscible liquid (dichloromethane: CH2Cl2, 100 mL, places 2 and 3) with the circulating fluid (water, 1350 mL, places 1, A, B) was placed. Malachite Green (MG) was introduced as solute into the system (place 1,5 mL, 700 mg/L aqueous solution). The pump output was set at 1080 mL/min, serving more fluid (five times) to flask A than to flask B. Samples were drawn from compartments 1, A and B, and from organic compartments, during experiences taking several hours. MG concentrations were colorimetrically measured at 619 nm. Room temperature was between 15–25 °C. CH2Cl2 MG concentration ratio ([2]/[3]) was similar to fluid flow ratio (σ/(1-σ)) all over the experience time. Other experiences changing the stop time, room temperature, CH2Cl2 volumes and places, pump output distribution, led us to different evidences that supported a theoretical model. As a conclusion, the most important feature was that whereas MG concentrations in water (1, A, B) were close, in CH2Cl2 these were very different. So, is drug effect prediction reliable by monitoring free drug concentrations in blood? European Journal of Drug Metabolism and Pharmacokinetics European Journal of Drug Metabolism and Pharmacokinetics Look Inside Article Metrics 3 Citations Co-published with Adis Adis Other actions Export citation Register for Journal Updates About This Journal Reprints and Permissions Add to Papers Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn

Autor

Fagiolino, Pietro
Wilson, F.
Samaniego, E.
Vazquez, M.

Fuente

European Journal of Drug Metabolism and Pharmacokinetics v. 28, no. 2, 2003. -- p. 147-153

Editor

Springer

Fecha

2003

Derechos

Información sobre Derechos de Autor

(Por favor lea este aviso antes de abrir los documentos u objetos)

La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.

Formato

PDF

Idioma

Inglés

Tipo

Artículo

Identificador

DOI: 10.1007/BF03190504
Fecha de agregación
February 20, 2015
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
, ,
Citación
Fagiolino, Pietro, “In vitro approach to study the influence of the cardiac output distribution on drug concentration,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed August 21, 2019, http://riquim.fq.edu.uy/items/show/2436.
Archivos