Contribution of C5-mediated mechanisms to host defense against Echinococcus granulosus hydatid infection

QUISTE HIDATICO

ECHINOCOCCUS GRANULOSUS

INMUNOLOGIA

BIBLIOGRAFIA NACIONAL QUIMICA

2000

The aim of this work was to investigate the contribution of complement C5-mediated mechanisms, with an emphasis on in¯ammation, to host defences against Echinococcus granulosus hydatid disease. Thus, we compared the systemic and local in¯ammatory responses induced by the parasite, and the outcome of infection, between congenic C5-suf®cient (B10.D2 n/SnJ) and C5-de®cient (B10.D2 o/SnJ) mice challenged with protoscoleces. Indirect evidence of in-vivo complement activation during the establishment phase was obtained; infection induced serum amyloid P and eosinophil responses which were dependent on C5. Early recruitment of polymorphonuclear cells was not dependent on the presence of C5. The higher capacity of C5-suf®cient mice to recruit eosinophils was also observed during the cystic phase of infection, and mice recruiting more eosinophils developed lower parasite masses. Analysis of the outcome of infection after 8 months showed that C5-suf®cient mice were more resistant to infection than C5-de®cient mice in terms of individuals with no cysts; this trend was not statistically signi®cant. In addition, C5-de®cient mice developed higher numbers of large (> 5mm in diameter) cysts and higher cyst weights than C5-suf®cient mice indicating that C5-mediated mechanisms are detrimental for parasite growth. Taken together, our results suggest that complement, through C5-mediated effectors, contributes to host defences by both restricting the establishment of infection and controlling the growth of established cysts. This contribution may, at least partially, be associated with the ability of C5a to promote eosinophil in®ltration.

Parasite Immunology v. 22, , 2000. -- p. 445-453

Blackwell Science Ltd

2000

Información sobre Derechos de Autor

(Por favor lea este aviso antes de abrir los documentos u objetos)

La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)

ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.

PDF

Inglés

Artículo

DOI: 10.1046/j.1365-3024.2000.00323.x