Contribution of C5-mediated mechanisms to host defense against Echinococcus granulosus hydatid infection

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Contribution of C5-mediated mechanisms to host defense against Echinococcus granulosus hydatid infection

Tema

QUISTE HIDATICO
ECHINOCOCCUS GRANULOSUS
INMUNOLOGIA
BIBLIOGRAFIA NACIONAL QUIMICA
2000

Abstract

The aim of this work was to investigate the contribution of complement C5-mediated mechanisms, with an emphasis on in¯ammation, to host defences against Echinococcus granulosus hydatid disease. Thus, we compared the systemic and local in¯ammatory responses induced by the parasite, and the outcome of infection, between congenic C5-suf®cient (B10.D2 n/SnJ) and C5-de®cient (B10.D2 o/SnJ) mice challenged with protoscoleces. Indirect evidence of in-vivo complement activation during the establishment phase was obtained; infection induced serum amyloid P and eosinophil responses which were dependent on C5. Early recruitment of polymorphonuclear cells was not dependent on the presence of C5. The higher capacity of C5-suf®cient mice to recruit eosinophils was also observed during the cystic phase of infection, and mice recruiting more eosinophils developed lower parasite masses. Analysis of the outcome of infection after 8 months showed that C5-suf®cient mice were more resistant to infection than C5-de®cient mice in terms of individuals with no cysts; this trend was not statistically signi®cant. In addition, C5-de®cient mice developed higher numbers of large (> 5mm in diameter) cysts and higher cyst weights than C5-suf®cient mice indicating that C5-mediated mechanisms are detrimental for parasite growth. Taken together, our results suggest that complement, through C5-mediated effectors, contributes to host defences by both restricting the establishment of infection and controlling the growth of established cysts. This contribution may, at least partially, be associated with the ability of C5a to promote eosinophil in®ltration.

Autor

Ferreira, A.M
Breijo, M
Sim, R.B

Fuente

Parasite Immunology v. 22, , 2000. -- p. 445-453

Editor

Blackwell Science Ltd

Fecha

2000

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Identificador

DOI: 10.1046/j.1365-3024.2000.00323.x
Fecha de agregación
April 29, 2015
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Ferreira, A.M, “Contribution of C5-mediated mechanisms to host defense against Echinococcus granulosus hydatid infection,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed December 8, 2019, http://riquim.fq.edu.uy/items/show/2923.
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