Echinococcus granulosus : heterogeneity and differential expression of superoxide dismutases

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Echinococcus granulosus : heterogeneity and differential expression of superoxide dismutases




Reactive oxygen species (ROS) are an inescapable consequence of and geographical regions (Lymbery and Thompson 1988). We have aerobic metabolism: the sequential reduction of oxygen to water pro- started to characterize the antioxidant enzymes of E. granulosus, the duces superoxide radical and hydrogen peroxide. These species may causative agent of hydatid disease. While thioredoxin peroxidase may have potentially deleterious effects, since they can interact with each be the main hydrogen peroxide-metabolizing enzyme of this organism other and with cellular components, leading to radical chain reactions (Salinas et al. 1998), the results presented in this article suggest that and ultimately to cell death. Antioxidant enzymes constitute a natural regulatory system which has evolved to enable aerobic organisms to CuZnSOD activity is developmentally regulated in E. granulosus and employ oxidative metabolismwhile being protected fromthe damaging actively secreted by protoscoleces. effects of its by-products (Halliwell and Gutteridge 1999). Parasitic All E. granulosus extracts assayed possessed CuZnSOD activity organisms have an additional requirement for these enzymes, since (Table I), which was highest in protoscoleces (PSC). MnSOD activity they may also be exposed to oxidizing agents derived fromhost effector was detected only in PSC and prepatent adult worm extracts, constitutcells (Callahan et al. 1988; LoVerde 1998; Selkirk et al. 1998). It is ing less than 15% of the total SOD activity in either case. The specific thought that they have adapted to this stress by synthesizing high activity in PSC E/S products was about five times greater than that of levels of antioxidant enzymes and expressing them at the host–parasite the extract, suggesting that CuZnSOD is actively secreted in vitro by interface; for instance, several variants of helminth antioxidant enzymes PSC. Low levels of CuZnSOD activity were detected in hydatid fluid are localized to the tegument or the cuticle and are released into their (HF), indicative of in vivo secretion of the enzyme, and in hydatid immediate environment (Cookson et al. 1992; Tang et al. 1995; Mei


Cardozo, S


Experimental Parasitology v. 94, , 2000. -- p. 56-59


Academic Press




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Fecha de agregación
May 20, 2015
Bibliografía Nacional Química
Tipo de Elemento
Salinas, Gustavo, “Echinococcus granulosus : heterogeneity and differential expression of superoxide dismutases,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed May 30, 2020,