Antibody response of Echinococcus granulosus infected mice : Protoscolex specific response during infection is associated with decreasing specific IgG1/IgG3 ratio as well as decreasing avidity.

Dublin Core

Título

Antibody response of Echinococcus granulosus infected mice : Protoscolex specific response during infection is associated with decreasing specific IgG1/IgG3 ratio as well as decreasing avidity.

Tema

ECHINOCOCCUS GRANULOSUS
INMUNOGLOBULINA-IgG
BIBLIOGRAFIA NACIONAL QUIMICA
1997

Abstract

The antibody response was followed during 68 weeks in 17 Balb/c mice intraperitoneally (i.p.) infected with Echinococcus granulosus protoscoleces (PSC) and in three mice i.p. immunized with dead PSC. Titres of antibodies recognizing peptidic and glucidic PSC epitopes, as well as their isotypic and avidity profiles were followed by ELISA. In addition, antigen recognition patterns were analysed by immunoblot. The response against carbohydrate epitopes was dominant in infected and immunized mice but stronger in the first group. Infected mice showed similar profiles of specific IgG and IgM with maximum titres from week 38 to 53. Although IgG1 and IgG3 were the predominant antibody subclasses, the ratio of IgG1/IgG3 antibody titres as well as antibody avidity decreased during the experiment, encompassing a decrease in recognition of peptidic epitopes. Immunized mice did not show significant levels of specific IgM and, after week 15, showed IgG titres lower than the infected mice. IgG1 was the predominant IgG subclass during all the experiment with background levels of IgG3. The mean Ab avidity was high and showed no significant changes during immunization. Different patterns of response were thus produced by dead and developing live parasites. Although high avidity IgG1 antibodies were early found in both cases, lower avidity IgG3 antibodies were increasingly produced afterwards only in infected animals. The isotype switch and avidity decrease observed only during infection are consistent with a possible parasitic mechanism to evade host immunity.

Autor

Severi, M
Ferragut, G

Fuente

Parasite Immunology v. 19, , 1997. -- p. 545-552

Editor

Wiley

Fecha

1997

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PDF

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Tipo

Artículo

Identificador

DOI: 10.1046/j.1365-3024.1997.d01-172.x

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PDF
Fecha de agregación
September 23, 2015
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
,
Citación
Severi, M, “ Antibody response of Echinococcus granulosus infected mice : Protoscolex specific response during infection is associated with decreasing specific IgG1/IgG3 ratio as well as decreasing avidity.,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed June 14, 2024, https://riquim.fq.edu.uy/items/show/3472.
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