Low-level arsenic exposure : Nutritional and dietary predictors in first-grade Uruguayan children

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Título

Low-level arsenic exposure : Nutritional and dietary predictors in first-grade Uruguayan children

Tema

ARSENICO
TOXICOLOGIA
NIÑOS
ARSENICO URINARIO
BIBLIOGRAFIA NACIONAL QUIMICA
2016

Abstract

Arsenic exposure in children is a public health concern but is understudied in relation to the predictors, and effects of low-level exposure. We examined the extent and dietary predictors of exposure to inorganic arsenic in 5–8 year old children from Montevideo, Uruguay. Children were recruited at school; 357 were enrolled, 328 collected morning urine samples, and 317 had two 24-h dietary recalls. Urinary arsenic metabolites, i.e. inorganic arsenic (iAs), methylarsonic acid (MMA), and dimethylarsinic acid (DMA), were measured using high-performance liquid chromatography with hydride generation and inductively coupled plasma mass spectrometry (HPLC-HG-ICP-MS), and the sum concentration (U-As) used for exposure assessment. Proportions of arsenic metabolites (%iAs, %MMA and %DMA) in urine were modelled in OLS regressions as functions of food groups, dietary patterns, nutrient intake, and nutritional status. Exposure to arsenic was low (median U-As: 9.9 mg/L) and household water (water As: median 0.45 mg/L) was not a major contributor to exposure. Children with higher consumption of rice had higher U-As but lower %iAs, %MMA, and higher %DMA. Children with higher meat consumption had lower %iAs and higher %DMA. Higher scores on “nutrient dense” dietary pattern were related to lower %iAs and % MMA, and higher %DMA. Higher intake of dietary folate was associated with lower %MMA and higher % DMA. Overweight children had lower %MMA and higher %DMA than normal-weight children. In summary, rice was an important predictor of exposure to inorganic arsenic and DMA. Higher meat and folate consumption, diet rich in green leafy and red-orange vegetables and eggs, and higher BMI contributed to higher arsenic methylation capacity

Autor

Kordas, Katarzyna
Queirolo, Elena I.
Peregalli, Fabiana
Ying Hsiao, Pao
Lu, Ying
Vahter, Marie

Fuente

Environmental Research v. 147, 2016. -- p. 16-23

Editor

Elsevier

Fecha

2016

Derechos

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PDF

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Artículo

Identificador

http://dx.doi.org/10.1016/j.envres.2016.01.022

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PDF
Fecha de agregación
May 10, 2016
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Kordas, Katarzyna, “Low-level arsenic exposure : Nutritional and dietary predictors in first-grade Uruguayan children,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed January 27, 2020, http://riquim.fq.edu.uy/items/show/3977.
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