Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients

Dublin Core

Título

Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients

Tema

NEOPLASMA
CANCER GASTRICO
BIBLIOGRAFIA NACIONAL QUIMICA
2016

Abstract

Gastric cancer (GC) is the third most common cause of cancer death worldwide. Natural killer cells play an important role in the immune defense against transformed cells. They express the activating receptor NKG2D, whose ligands belong to the MIC and ULBP/RAET family. Although it is well established that these ligands are generally expressed in tumors, the association between their expression in the tumor and gastric mucosa and clinical parameters and prognosis of GC remains to be addressed. In the present study, MICA and MICB expression was analyzed, by flow cytometry, in 23 and 20 pairs of gastric tumor and adjacent non-neoplasic gastric mucosa, respectively. Additionally, ligands expression in 13 tumors and 7 gastric mucosa samples from GC patients were evaluated by immunohistochemistry. The mRNA levels of MICA in 9 pairs of tumor and mucosa were determined by quantitative PCR. Data were associated with the clinicopathological characteristics and the patient outcome. MICA expression was observed in 57% of tumors (13/23) and 44% of mucosal samples (10/23), while MICB was detected in 50% of tumors (10/20) and 45% of mucosal tissues (9/20). At the protein level, ligand expression was significantly higher in the tumor than in the gastric mucosa. MICA mRNA levels were also increased in the tumor as compared to the mucosa. However, clinicopathological analysis indicated that, in patients with tumors >5 cm, the expression of MICA and MICB in the tumor did not differ from that of the mucosa, and tumors >5 cm showed significantly higher MICA and MICB expression than tumors ≤5 cm. Patients presenting tumors >5 cm that expressed MICA and MICB had substantially shorter survival than those with large tumors that did not express these ligands. Our results suggest that locally sustained expression of MICA and MICB in the tumor may contribute to the malignant progression of GC and that expression of these ligands predicts an unfavorable prognosis in GC patients presenting large tumors.

Autor

Ribeiro, C. H.
Kramm, K.
Gálvez-Jirón, F.
Pola, V.
Bustamante, M.
Contreras, H. R.
Sabag, A.
Garrido-Tapia, M.
Hernández, C.J.
Zúñiga, R.
Collazo, N.
Sotelo, P. H.
Morales, C.
Mercado, L.
Catalán, D.
Aguillón, J. C.
Molina, M. C.

Fuente

Oncology Reports  v. 35, no. 3, 2016. -- p. 1309-1317

Editor

Spandidos Publicatons

Fecha

2016

Derechos

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Formato

PDF

Idioma

Inglés

Tipo

Artículo

Identificador

DOI: 10.3892/or.2015.4510

Document Item Type Metadata

Original Format

PDF
Fecha de agregación
June 23, 2017
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
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Citación
Ribeiro, C. H., “Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed September 15, 2019, http://riquim.fq.edu.uy/items/show/4628.
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