Heteroleptic oxidovanadium(IV) complexes of 2-hydroxynaphtylaldimine and polypyridyl ligands against Trypanosoma cruzi and prostate cancer cells

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Título

Heteroleptic oxidovanadium(IV) complexes of 2-hydroxynaphtylaldimine and polypyridyl ligands against Trypanosoma cruzi and prostate cancer cells

Tema

VANADIO
ANTITRIPANOSOMAS
TRIPANOSOMA CRUZI
AGENTES ANTITUMORALES
BIBLIOGRAFIA NACIONAL QUIMICA
2017

Abstract

In Latin America Chagas disease is an endemic illness caused by the parasite Trypanosoma cruzi (T. cruzi), killing more people than any other parasitic disease. Current chemotherapies are old and inadequate, thus the development of efficient ones is urgently needed. Vanadium-based complexes have been shown to be a promising approach both against parasitic diseases and cancer and this study aims to achieve significant advances in the pursue of effective compounds. Heteroleptic vanadium complexes of Schiff bases and polypyridine compounds were prepared and their stability in solution evaluated by EPR (Electronic Paramagnetic Resonance) and NMR spectroscopy. Their in vitro activities were evaluated against T. cruzi and a set of cells lines representative of human cancer conditions, namely ovarian, breast and prostate cancer. In T. cruzi, most of the complexes depicted IC50 values in the low μM range, induced changes of mitochondrial membrane potential and apoptosis. In cancer cells, complexes showed good to moderate activity and in metastatic cells (prostate PC3), some complexes inhibited the migratory ability, this suggesting that they display antimetastatic potential. Interestingly, complex 5 seemed to have a dual effect being the most cytotoxic complex on all cancer cells and also the most active anti-T-cruzi compound of the series. Globally the complexes showed promising anticancer and anti T. cruzi activities and also displayed some characteristics indicating they are worth to be further explored as antimetastatic drugs.

Autor

Scalese, Gonzalo
Mosquillo, M. Florencia
Rostán, Santiago
Pérez, Leticia.
Correia, Isabel
Marques, Fernanda
Costa Pessoa, João

Fuente

Journal of Inorganic Biochemistry v. 175, 2017. -- p. 154-166

Editor

Elsevier

Fecha

2017

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Artículo

Identificador

DOI: 10.1016/j.jinorgbio.2017.07.014

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PDF
Fecha de agregación
December 14, 2017
Colección
Bibliografía Nacional Química
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Document
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Citación
Scalese, Gonzalo, “Heteroleptic oxidovanadium(IV) complexes of 2-hydroxynaphtylaldimine and polypyridyl ligands against Trypanosoma cruzi and prostate cancer cells,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed August 14, 2018, http://riquim.fq.edu.uy/items/show/4805.
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