Variability of matrix effects inliquid and gas chromatography -mass spectrometry analysis of pesticide residues after QuEChERS sample preparation of different food crops

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Título

Variability of matrix effects inliquid and gas chromatography -mass spectrometry analysis of pesticide residues after QuEChERS sample preparation of different food crops

Tema

PESTICIDAS
RESIDUOS DE PESTICIDAS
CROMATOGRAFIA DE GASES
ESPECTROMETRIA DE MASAS
BIBLIOGRAFIA NACIONAL QUIMICA
2012

Abstract

Gas and liquid chromatography (GC and LC) coupled to mass spectrometry (MS) serve as the most powerful analytical tools commonly used to monitor pesticide residues in food, among other applications. However, both GC–MS and LC–MS are susceptible to matrix effects which can adversely affect quantification depending on the analyte, matrix, sample preparation, instrumentation, and operating conditions. Among the approaches that reduce matrix effects, the most common in pesticide residue applications is matrix-matched calibration because it is relatively inexpensive and simple. Also, it has been shown to work well during method validation when fortified samples are exactly matched with samples used for calibration. However, the quality of matrix-matched results in real-world analyses depends on the consistency of matrix effects among diverse samples. In this study, the variability of matrix effects was measured for 38 representative pesticides in 20 samples each (including different varieties) of rice, orange, apple, and spinach extracted using the “quick, easy, cheap, effective, rugged, and safe” (QuEChERS) method for analysis by LC–MS/MS and low-pressure GC–MS. Using LC–MS/MS, only oranges gave >20% matrix effects for a few pesticides. GC–MS exhibited larger matrix effects, but as in LC–MS/MS, the differences were reasonably consistent among the 20 samples tested. Main conclusions of this study are that for the conditions utilized: (1) matrix-matching was not needed for most pesticides in the simpler food matrices; and (2) for the more complex orange matrix, acceptably accurate quantitative results were achieved by using matrix-matching even with a different sample of the same type. However, full confidence cannot be extended to matrix-matched results, and for consequential applications such as regulatory enforcement, confirmatory analyses using alternate quantitative determinations should also be conducted.

Autor

Kwon, H.
Lehotay, S. J.
Geis Asteggiante, Lucía

Fuente

Journal of Chromatography A. v. 1270, 2012. -- p. 235-245

Editor

Elsevier

Fecha

2012

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Artículo

Identificador

http://dx.doi.org/10.1016/j.chroma.2012.10.059
Fecha de agregación
May 28, 2013
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Kwon, H., “Variability of matrix effects inliquid and gas chromatography -mass spectrometry analysis of pesticide residues after QuEChERS sample preparation of different food crops,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed October 18, 2018, http://riquim.fq.edu.uy/items/show/505.
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