The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components

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The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components

Tema

DISPERSION SOLIDA
FORMULACION
ESPECTROSCOPIA RAMAN
BIBLIOGRAFIA NACIONAL QUIMICA
2018

Abstract

Purpose Solid dispersions (SDs) of a poorly water-soluble drug were prepared, and their physicochemical properties were compared to those of control physical mixtures (PMs). Among the multiple techniques used to characterize the solid state of preparations, confocal micro Raman spectroscopy (CMRS) was used as a non-destructive tool to qualitatively probe content uniformity and distribution of drug and carrier. Methods SDs and PMs of drug (fenbendazole, FBZ) were prepared containing two different carriers (poloxamer P188 or P407) with different drug polymer ratios. The preparations were characterized by powder X-ray diffractometry, Fourier transform infrared spectroscopy, thermal analysis, scanning electron microscopy, and in vitro dissolution assay. In addition, CMRS technique and principal component analysis (PCA) were used in order to statistically define the content uniformity and distribution of the drug within the polymeric matrix. Results In vitro dissolution results exhibited a marked improvement when the drug was formulated as SD compared to control PM and to pure drug. The solid state of these preparations characterized by X-ray powder diffraction and Fourier transform infrared spectroscopy showed no changes in the crystalline state of the drug and no chemical interactions between the components. Raman studies showed a better content uniformity of the drug within the polymeric matrix when subjected to SD process, correlating with the improved dissolution profile. Conclusion This study provides evidence of the potential of the confocal Raman imaging technique, providing a fast and powerful method to characterize solid dispersions which could be incorporated towards the use of quality by design (QbD) approaches in pharmaceutical development.

Autor

Melian, M. Elisa
Munguía, A. Beatriz
Palma, Santiago

Fuente

Journal of Pharmaceutical Innovation |g v. 13, 2018. -- p. 58-68

Editor

Springer

Fecha

2018

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PDF

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Inglés

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Artículo

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PDF
Fecha de agregación
October 25, 2018
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Melian, M. Elisa, “The Impact of Solid Dispersion on Formulation, Using Confocal Micro Raman Spectroscopy as Tool to Probe Distribution of Components,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed October 22, 2020, http://riquim.fq.edu.uy/items/show/5275.
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