Acute effect of vaporized Cannabis on sleep and electrocortical activity

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Título

Acute effect of vaporized Cannabis on sleep and electrocortical activity

Tema

MARIHUANA
MARIHUANA MEDICINAL
INSOMNIO
SUEÑO
BIBLIOGRAFIA NACIONAL QUIMICA
2019

Abstract

The use of Cannabis for medical purposes is rapidly expanding and is usually employed as a self-medication for the treatment of insomnia disorder. However, the effect on sleep seems to depend on multiple factors such as composition of the Cannabis, dosage and route of administration. Vaporization is the recommended route for the administration of Cannabis for medical purposes; however, there is no published research about the effects of vaporized Cannabis on sleep, neither in laboratory animals, nor in humans. Because previous reports suggested that low doses of THC have sedating effects, the aim of the present study was to characterize in rats, the acute effects on sleep induced by the administration of low doses of THC by means of vaporization of a specific type of Cannabis (THC 11.5% and negligible amounts of other cannabinoids). For this purpose, polysomnographic recordings in chronically prepared rats were performed during 6 h in the light and dark phases. Animals were treated with 0 (control), 40, 80 and 200 mg of Cannabis immediately before the beginning of recordings; the THC plasma concentrations with these doses were low (up to 6.7 ng/mL with 200 mg). A quantitative EEG analyses by means of the spectral power and coherence estimations was also performed for the highest Cannabis dose. Compared to control, 200 mg of Cannabis increased NREM sleep time during the light phase, but only during the first hour of recording. Interestingly, no changes on sleep were observed during the dark (active) phase or with lower doses of Cannabis. Cannabis 200 mg also produced EEG power reductions in different cortices, mainly for high frequency bands during W and REM sleep, but only during the light phase. On the contrary, a reduction in the sleep spindles intra-hemispheric coherence was observed during NREM sleep, but only during the dark phase. In conclusion, administration of low doses of THC by vaporization of a specific type of Cannabis produced a small increment of NREM sleep, but only during the light (resting) phase. This was accompanied by subtle modifications of high frequency bands power (during the light phase) and spindle coherence (during the dark phase), which are associated with cognitive processing. Our results reassure the importance of exploring the sleep-promoting properties of Cannabis.

Autor

Mondino, Alejandra
Cavelli, Matías
González Arbildi, Joaquín.
Santana, Noelia
Castro Zaballa, Santiago
Mechoso, Búrix
Brasesco, Nelson
Fernández, Santiago
García Carnelli, Carlos
Castro, María José
Umpiérrez, Eleuterio
Murillo Rodríguez, Eric
Torterolo, Pablo
Falconi, Atilio

Fuente

Pharmacology, Biochemistry and Behavior  v. 179, 2019. -- p. 113-123

Editor

Elsevier

Fecha

2019

Derechos

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Formato

PDF

Idioma

Inglés

Tipo

Artículo

Identificador

DOI: 10.1016/j.pbb.2019.02.012

Document Item Type Metadata

Original Format

PDF
Fecha de agregación
November 14, 2019
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Mondino, Alejandra, “Acute effect of vaporized Cannabis on sleep and electrocortical activity,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed May 29, 2020, http://riquim.fq.edu.uy/items/show/5895.
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