Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose

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Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose

Tema

CANNABIS
COMPORTAMIENTO SEXUAL FEMENINO
CANNABIS VAPORIZADO
BIBLIOGRAFIA NACIONAL QUIMICA
2019

Abstract

Studies exploring the effect of compounds that modulate the endocannabinoid system on sexual behavior have yielded contradictory results. However, the effect of smoked Cannabis in women has been consistently associated with an increase in sexual drive. Therefore, it can be speculated that vaporized Cannabis will augment sexually motivated components of the sexual behavior of female rats. To test this hypothesis, we compared the sexual behavior of late-proestrous female rats in a bilevel chamber after vaporizing 0, 200 or 400 mg of Cannabis flowers (containing 18% of delta-9-THC and undetectable levels of cannabidiol) during 10 min. We found that both doses of Cannabis increased the duration of the lordosis response, whereas the highest dose also reduced the lordosis quotient of females. The lowest dose of Cannabis augmented the display of hops and darts without altering the expression of sexual solicitations of females, while the highest one did not affect the expression of hops and darts but reduced sexual solicitations. These effects were not accompanied by alterations of females' ambulatory behavior. The increment of the duration of lordosis response produced by both doses of Cannabis could be associated to a general effect of this drug in sensory processing, as can be an enhancement of females' sensory reactivity to male's stimulation. However, the reduction in the display of solicitations and lordosis in response to mounting observed in females exposed to the highest dose when compared to control and 200 mg of Cannabis groups indicates a reduction of sexual receptivity and motivation. This differential effect of vaporized Cannabis according to the dose employed, suggests that it modulates sexual behavior in a complex way, impacting neural circuits that control different aspects of this social behavior.

Autor

Mondino, Alejandra
Fernández, Santiago
Garcia Carnelli, Carlos
Castro, María José
Umpiérrez, Eleuterio
Torterolo, Pablo
Falconi, Atilio
Agrati, Daniella

Fuente

Pharmacology, Biochemistry and Behavior v. 187, 2019. -- p. 1-8.--e172814

Editor

Elsevier

Fecha

2019

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DOI:10.1016/j.pbb.2019.172814
Fecha de agregación
January 15, 2020
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Citación
Mondino, Alejandra, “Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed June 3, 2020, http://riquim.fq.edu.uy/items/show/5953.
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