Executive functions in school children from Montevideo, Uruguay and their associations with concurrent low-level arsenic exposure

Dublin Core

Título

Executive functions in school children from Montevideo, Uruguay and their associations with concurrent low-level arsenic exposure

Tema

ARSENICO
NIÑOS
VITAMINAS B
URUGUAY
BIBLIOGRAFIA NACIONAL QUIMICA
2020

Abstract

Objective: Arsenic is a known childhood neurotoxicant, but its neurotoxicity at low exposure levels is still not well established. The aim of our cross-sectional study was to test the association between low-level arsenic exposure and executive functions (EF) among children in Montevideo. We also assessed effect modification by arsenic methylation capacity, a susceptibility factor for the health effects of arsenic, and by B-vitamin intake, which impacts arsenic methylation. Methods: Arsenic exposure was assessed as the specific gravity-adjusted sum of urinary arsenic metabolites (UAs) among 255 ~ 7 year-old children, and methylation capacity as the proportion of urinary monomethylarsonic acid (%MMA). Arsenic concentrations from kitchen water samples at participants’ homes were assessed. Bvitamin intake was calculated from the average of two 24-hour dietary recalls. EF was measured using three tests from the Cambridge Neuropsychological Test Automated Battery – Stockings of Cambridge (SOC), Intra-dimensional/ extra-dimensional shift task (IED), and Spatial Span (SSP). Generalized linear models assessed the association between U-As and EF measures; models were adjusted for age, sex, maternal education, possessions score, Home Observation for Measurement of the Environment Inventory score, season, and school clusters. Additional analyses were conducted to address issues of residual confounding and sample size. A “B-vitamin index” was calculated using principal component analysis. Effect modification by the index and urinary %MMA was assessed in strata split at the respective medians of these variables. Results: The median (range) U-As and water arsenic levels were 9.9 μg/L (2.2, 47.7) and 0.45 μg/L (0.1, 18.9) respectively, indicating that exposure originated mainly from other sources. U-As was inversely associated with the number of stages completed (β = −0.02; 95% CI: −0.03, −0.002) and pre-executive shift errors (β = −0.08; 95% CI: −0.14, −0.02) of the IED task, and span length of the SSP task (β = −0.01; 95% CI: −0.02, −0.004). There was no clear pattern of effect modification by B-vitamin intake or urinary %MMA. Conclusion: Low-level arsenic exposure may adversely affect executive function among children but additional, including longitudinal, studies are necessary to confirm these findings.

Autor

Desai, Gauri
Barg, Gabriel
Vahter, Marie
Queirolo, Elena I.
Peregalli, Fabiana
Mañay, Nelly
Millen, Amy E.
Yu, Jihnhee
Kordas, Katarzyna

Fuente

Environment International v. 142 , 2020.-- p. 1- 9.--e 105883

Editor

Elsevier

Fecha

2020

Derechos

Información sobre Derechos de Autor (Por favor lea este aviso antes de abrir los documentos u objetos) La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006) ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.

Formato

Pdf

Idioma

Inglés

Tipo

Artículo

Identificador

https://doi.org/10.1016/j.envint.2020.105883

Cobertura

Uruguay

Document Item Type Metadata

Original Format

Pdf
Fecha de agregación
April 5, 2021
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
, , ,
Citación
Desai, Gauri 2.11.0.0, “Executive functions in school children from Montevideo, Uruguay and their associations with concurrent low-level arsenic exposure 2.11.0.0,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed April 23, 2021, http://riquim.fq.edu.uy/items/show/6218.
Archivos