Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs

Dublin Core

Título

Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs

Tema

TRYPANOSOMA CRUZI
TUBERCULOSIS
COMPUESTOS HETEROCICLICOS
QUINOXALINA
BIBLIOGRAFIA NACIONAL QUIMICA
2009

Abstract

Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1,4-di-N-oxide derivatives have been prepared and tested against M. tuberculosis and T. cruzi. Carboxylic acid quinoxaline 1,4-di-N-oxides (CAQDOs) 5 and 17 showed MIC values on the same order as the reference antituberculosis drug, rifampicin. Meanwhile, CAQDOs 12 and 22 presented IC50 values in the same order as the anti-chagasic drug, nifurtimox.

Autor

Ancizu, Saioa
Moreno, Elsa
Torres, Enrique
Burguete, Asunción
Pérez-Silanes, Silvia
Benítez, Diego
Villar, Raquel
Solano, Beatriz
Marín, Adoración
Aldana, Ignacio
Cerecetto, Hugo
González Hormaizteguy, María Mercedes
Monge, Antonio

Fuente

Molecules (Basel, Switzerland) v.14, no. 6, 2009. -- p.2256-2272

Editor

MDPI

Fecha

2009

Tipo

Artículo

Document Item Type Metadata

Original Format

PDF
Fecha de agregación
August 1, 2012
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
,
Citación
Ancizu, Saioa, “Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed December 13, 2017, http://riquim.fq.edu.uy/items/show/12.
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