177-Lu-Labeled agents for neuroendocrine tumor therapy and bone pain palliation in Uruguay
Dublin Core
Título
177-Lu-Labeled agents for neuroendocrine tumor therapy and bone pain palliation in Uruguay
Tema
NEUROLOGIA
NEOPLASICOS
URUGUAY
BIBLIOGRAFIA NACIONAL QUIMICA
2016
Abstract
Lutetium-177 is an emerging radionuclide due its convenient chemical and nuclear properties. In this paper we describe the development and evaluation in Uruguay of the targeted 177Lu labelled radiopharmaceuticals EDTMP (for bone pain palliation) and DOTA-TATE (neuroendocrine tumors). We optimized the preparation of these 177Lu radiopharmaceuticals including radiolabelling, quality control methods, in vitro and in vivo stability and their therapeutic application in patients. Radiation dosimetry aspects of 177Lu are also included. Nine male patients with prostate cancer and four female patients with breast carcinoma with multiple bone metastatic lesions were treated with 177Lu-EDTMP. Four patients with gastroentheropancreatic neuroendocrine tumors (GEP-NET) and one patient with bronchial NET were treated with 1- 3 cycles with a cumulative dose of 4.44-22.2 GBq of 177Lu-DOTA-TATE. Scintigraphic images of the patients treated with 177Lu-EDTMP evidenced high and rapid uptake in bone metastasis, remaining after 7 days post administration. Images allow skeletal visualization with high definition and demonstrate increased uptake in bone metastases. For 177Lu-DOTA-TATE, partial remissions were obtained in 4 patients and the remaining patient did not show significant progression 3 months after the second cycle. No serious adverse effects were registered, even in two patients with confirmed renal disease and high risk for renal disease Dosimetry assessments confirm the predictive value of the personalized therapy with radiolabelled peptides. We found it is possible to accumulate high therapeutic doses in tumours in sequential administrations of 177Lu-DOTA-TATE, increasing the probability of biological response without significant impairment ofthe renal function in patients with risk factors. These results demonstrate the attractive therapeutic properties of these two 177Lu labelled agents and the feasibility of this metabolic therapy in regions far away from 177Lu producing countries.
Autor
Balter, Henia
Trindade, V.
Gaudiano, J.
Ferrando, R.
Paolino, A.
Rodríguez, G.
Hermida, J.
De Marco, E.
Oliver, P.
Fuente
Current Radiopharmaceuticals v. 9, 2016. -- p. 85-93
Editor
Bentham Science Publishers
Fecha
2016
Formato
PDF
Idioma
Inglés
Tipo
Artículo
Identificador
ISSN : 1874-4729 (Electronic)
Cobertura
Uruguay
Document Item Type Metadata
Original Format
PDF
- Fecha de agregación
- December 4, 2015
- Colección
- Bibliografía Nacional Química
- Tipo de Elemento
- Document
- Etiquetas
- neoplásicos, Neurología, Uruguay
- Citación
- Balter, Henia, “177-Lu-Labeled agents for neuroendocrine tumor therapy and bone pain palliation in Uruguay,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed April 26, 2024, https://riquim.fq.edu.uy/items/show/3570.
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