Lipid-Free Antigen B Subunits from Echinococcus granulosus: Oligomerization, Ligand Binding, and Membrane Interaction Properties : Lipid-Free Antigen B Subunits from Echinococcus granulosus

Dublin Core

Título

Lipid-Free Antigen B Subunits from Echinococcus granulosus: Oligomerization, Ligand Binding, and Membrane Interaction Properties : Lipid-Free Antigen B Subunits from Echinococcus granulosus

Tema

HIDATIDOSIS
ANTIGENO B
ECHINOCOCCUS GRANULOSUS
BIBLIOGRAFIA NACIONAL QUIMICA
2015

Abstract

The hydatid disease parasite Echinococcus granulosus has a restricted lipid metabolism, and needs to harvest essential lipids from the host. Antigen B (EgAgB), an abundant lipoprotein of the larval stage (hydatid cyst), is thought to be important in lipid storage and transport. It contains a wide variety of lipid classes, from highly hydrophobic compounds to phospholipids. Its protein component belongs to the cestode-specific Hydrophobic Ligand Binding Protein family, which includes five 8-kDa isoforms encoded by a multigene family (EgAgB1-EgAgB5). How lipid and protein components are assembled into EgAgB particles remains unknown. EgAgB apolipoproteins self-associate into large oligomers, but the functional contribution of lipids to oligomerization is uncertain. Furthermore, binding of fatty acids to some EgAgB subunits has been reported, but their ability to bind other lipids and transfer them to acceptor membranes has not been studied.

Autor

Silva Alvarez, Valeria
Franchini, Gisela R.
Pórfido, Jorge L.
Kennedy, Malcolm W.
Córsico, Betina

Fuente

PLoS Neglected Tropical Diseases v. 9, no. 3, 2015. --e0003552, 23

Editor

Public Library of Science, San Francisco

Formato

PDF

Idioma

Inglés

Tipo

Artículo

Identificador

DOI: 10.1371/journal.pntd.0003552
Fecha de agregación
March 14, 2016
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
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Citación
Silva Alvarez, Valeria, “Lipid-Free Antigen B Subunits from Echinococcus granulosus: Oligomerization, Ligand Binding, and Membrane Interaction Properties : Lipid-Free Antigen B Subunits from Echinococcus granulosus,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed October 22, 2019, http://riquim.fq.edu.uy/items/show/3758.
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