Vasorelaxant Effect of a Baccharis trimera Infusion on Precontracted Rat Aortic Rings

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Vasorelaxant Effect of a Baccharis trimera Infusion on Precontracted Rat Aortic Rings

Tema

HIPERTENSION ARTERIAL
CARDIOLOGIA
VASODILATADORES
BACCHARIS TRIMERA
BIBLIOGRAFIA NACIONAL QUIMICA
2016

Abstract

Baccharis trimera (Less.) DC is a South American plant that in folk medicine is considered to produce reduction in blood pressure. One aspect of this putative effect is the vasorelaxation. The aim of this work was to evaluate the ability of a B. trimera extract to relax rat aortic rings precontracted with noradrenaline. As the infusion is the usual way of intake of this plant, an infusion of B. trimera was prepared using 100g of the plant (leaves) boiled in water, frozen and lyophilized. Working solutions were prepared using different concentrations of the dried extract diluted in Krebs Henseleit solution. It was proved that the infusion relaxed the aortic rings in a dose dependent manner 100 minutes after adding the extract to the bath. Considering as 100% the maximum contraction achieved with noradrenaline, a relaxation of 101.1±2.3% was observed with the highest dose of the infusion used in these experiments (0.32mg/mL). While in control rings relaxation was 12.9±2.4%. In aortic rings denuded from endothelium the percentage of vasoralaxation did not show statistically significant differences when compared to intact rings. These data support the hypothesis of a vasorelaxant effect of this plant and constitutes the first approach to the scientific basis of a potential antihypertensive effect. Keywords: Hypertension, Cardiovascular, Traditional medicine, Meso-and Southtern American, Baccharis trimera, Vasorelaxation, Aortic rings. Discover the world's research

Autor

Gómez, María A.
Miguez, Ignacio
Caggiani, María
Arias, Ximena
Laprovitera, Mariajosé
Blanco, Fabiana
Migliaro, Eduardo R.

Fuente

Natural Product Communications v. 11, no. 3, 2016. -- p. 283-286

Editor

NPC

Fecha

2016

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PDF

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Inglés

Tipo

Artículo

Identificador

ISSN 1934-578X

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Original Format

PDF
Fecha de agregación
October 26, 2016
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Gómez, María A., “Vasorelaxant Effect of a Baccharis trimera Infusion on Precontracted Rat Aortic Rings,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed September 28, 2020, http://riquim.fq.edu.uy/items/show/4478.
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