Polysaccharide Absorbents in Moisture Activated Dry Granulation

Dublin Core

Título

Polysaccharide Absorbents in Moisture Activated Dry Granulation

Tema

POLISACARIDOS
GRANULACION SECA
DISEÑO DE EXPERIMENTOS
BIBLIOGRAFIA NACIONAL QUIMICA
2018

Abstract

The aim of the present work was to study the hydrogel-forming polysaccharides carrageenan, guar and xanthan gum as potential absorbents in moisture activated dry granulation (MADG). Preferences of formulators regarding absorbents tend to incline towards microcrystalline cellulose and colloidal silicon dioxide. Besides, only few works exploring modified drug release achieved by MADG are reported in literature. A factorial design of experiments was introduced to study the effect of formulation variables on granulates and their tablets. Contact angle and drop penetration time provided useful information for guidance on excipient selection. Metronidazole was used as a highly soluble model drug to verify the release performance achieved with the polysaccharides. All of the granulates yielded tablets with appropriate physical properties, and significantly different disintegration behaviors and drug release profiles. Absorbent, binder and their mutual interaction had significant effects on formulation performance. The type of absorbent affected tablet disintegration time and drug release. The presence of copovidone, alone or in combination with povidone, proved to be a good choice for granulating a high load of not directly compressible materials by MADG. Carrageenan, guar and xanthan gum should be regarded as promising moisture absorbents for either immediate or extended release tablet formulations produced by MADG, an energy and time efficient granulation process. A broader range of absorbents could provide more versatility in MADG formulation and this advantageous process become more eligible for producing modified release products.

Autor

Ochoa Andrade, Ana
Fierro, M. V.
Bauzan, M. L.
Origoni, M. X.
Trezza, W. M.

Fuente

Science Forecast Journal of Pharmaceutical and Analytical Chemistry v. 1, 2018. -- 7p.--e1010

Editor

Scienceforecastoa

Fecha

2018

Formato

PDF

Idioma

Inglés

Tipo

Artículo

Identificador

ISSN: 2471-2698

Document Item Type Metadata

Original Format

PDF
Fecha de agregación
September 28, 2018
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
, ,
Citación
Ochoa Andrade, Ana, “Polysaccharide Absorbents in Moisture Activated Dry Granulation,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed December 13, 2019, http://riquim.fq.edu.uy/items/show/5176.
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