Antibody Profile of Colostrum and the Effect of Processing in Human Milk Banks : Implications in Immunoregulatory Properties

Dublin Core

Título

Antibody Profile of Colostrum and the Effect of Processing in Human Milk Banks : Implications in Immunoregulatory Properties

Tema

BANCOS DE LECHE
LECHE MATERNA
LECHE MATERNA
CUIDADO INFANTIL
LACTANTE PREMATURO TARDIO
PROPIEDADES INMUNOREGULADORAS
BIBLIOGRAFIA NACIONAL QUIMICA
2018

Abstract

BACKGROUND: When feeding preterm infants, donor milk is preferred if the mother's own milk is unavailable. Pasteurization may have detrimental effects on bioactivity, but more information is needed about its effects on the immunological compounds. Research aim: This work has two main aims: evaluate the antibody profile of colostrum and study the quantitative variations in the antibodies' level and specific reactivity after undergoing Holder pasteurization. The authors focused on immunoregulatory components of colostrum (antidietary antibodies and TGF-β2) in the neonatal gut. METHODS: This is a descriptive cross-sectional study of a convenience sample of 67 donated colostrum samples at different days after delivery, both raw and pasteurized. Antibody profiles were analyzed at different times during breastfeeding, and total and specific antibodies (IgM, IgA, and IgG subclasses) were compared with tetanus toxoid and ovalbumin using enzyme-linked immunosorbent assay. The processing effect on total and specific antibodies, as well as TGF-β2, was evaluated by paired analyses. RESULTS: No variations in immunological compounds were observed throughout the colostrum stage. The TGF-β2, antibodies' concentrations, and antibodies' specific reactivity after pasteurization did not vary significantly as days of lactation varied. Changes in antibody levels were dependent on isotype and IgG subclass, and IgG4 showed remarkable resistance to heating. Moreover, the effect of the pasteurization on specific reactivity was antigen dependent. CONCLUSION: The supply of relevant immunological components is stable throughout the colostrum stage. The effects of pasteurization on antibodies depend on isotype, subclass, and specificity. This information is relevant to improving the immunological quality of colostrum, especially for preterm newborns.

Autor

Rodríguez Camejo, Claudio
Puyol, Arturo
Fazio, Laura
Rodríguez, Analía
Villamil, Emilia
Andina, Eliana
Cordobez, Vanira
Díaz, Hernán
Lemos, Mary
Siré, Gabriela
Carroscia, Lilián
Castro, Mara
Panizzolo, Luis Alberto
Hernández, Ana

Fuente

Journal of Human Lactation v. 34, no. 1, 2018.-- p. 137-147

Editor

SAGE

Fecha

2018

Derechos

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Formato

PDF

Idioma

Inglés

Tipo

Artículo

Identificador

DOI: 10.1177/0890334417706359

Document Item Type Metadata

Original Format

PDF
Fecha de agregación
October 23, 2018
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Rodríguez Camejo, Claudio, “Antibody Profile of Colostrum and the Effect of Processing in Human Milk Banks : Implications in Immunoregulatory Properties,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed March 2, 2021, http://riquim.fq.edu.uy/items/show/5261.
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