Identification and Quantification of Cocaine and Active Adulterants in Coca-Paste Seized Samples : Useful Scientific Support to Health Care

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Título

Identification and Quantification of Cocaine and Active Adulterants in Coca-Paste Seized Samples : Useful Scientific Support to Health Care

Tema

CAFEINA
CROMATOGRAFIA DE GASES
ESPECTROMETRIA DE MASA
FENACETINA
BIBLIOGRAFIA NACIONAL QUIMICA
2018

Abstract

Adulteration is a common practice in the illicit drugs market, but the psychoactive and toxic effects provided by adulterants are clinically underestimated. Coca-paste (CP) is a smokable form of cocaine which has an extremely high abuse liability. CP seized samples are sold adulterated; however, qualitative and quantitative data of CP adulteration in forensic literature is still scarce. Besides, it is unknown if adulterants remain stable when CP is heated. This study was designed to report the chemical content of an extensive series of CP seized samples and to demonstrate the stability (i.e., chemical integrity) of the adulterants heated. To achieve this goal, the following strategies were applied: (1) a CP adulterated sample was heated and its fume was chemically analyzed; (2) the vapor of isolated adulterants were analyzed after heating; (3) plasma levels of animals exposed to CP and adulterants were measured. Ninety percent of CP seized samples were adulterated. Adulteration was dominated by phenacetin and caffeine and much less by other compounds (i.e., aminopyrine, levamisole, benzocaine). In the majority of CP analyzed samples, both cocaine and caffeine content was 30%, phenacetin 20% and the combination of these three components reached 90%. Typical cocaine pyrolysis compounds (i.e., BA, CMCHTs, and AEME) were observed in the volatilized cocaine and CP sample but no pyrolysis compounds were found after isolated adulterants heating. Cocaine, phenacetin, and caffeine were detected in plasma. We provide current forensic data about CP seized samples and demonstrated the chemical integrity of their adulterants heated.

Autor

Abin Carriquiry, Juan Andrés
Martínez Bussi, Marcela
Galvalisi, Martín.
Minteguiaga, Manuel
Prieto, José Pedro.
Scorza, María Cecilia

Fuente

Neurotoxicity Research v. 34, no. 2, 2018. --p. 295-304

Editor

Springer

Fecha

2018

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PDF

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Artículo

Identificador

DOI: 10.1007/s12640-018-9887-1.

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Original Format

PDF
Fecha de agregación
November 8, 2018
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Abin Carriquiry, Juan Andrés, “Identification and Quantification of Cocaine and Active Adulterants in Coca-Paste Seized Samples : Useful Scientific Support to Health Care,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed November 14, 2018, http://riquim.fq.edu.uy/items/show/5351.
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