Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children

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Título

Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children

Tema

ARSENICO
URUGUAY
BIBLIOGRAFIA NACIONAL QUIMICA
2018

Abstract

Oxidative stress (OS) is an important consequence of exposure to toxic metals but it is unclear to what extent low-level metal exposures contribute to OS in children. We examined the cross-sectional association between urinary concentrations of arsenic (As), cadmium (Cd), and lead (Pb) and urinary markers of OS: F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine (8-OHdG). We also tested effect modification by dietary intakes. Of the 211 children aged 6-8 years living in Montevideo who were eligible for the study because they had at least one OS marker measured via ELISA, 143 were included in a complete-case analysis. Urinary metals were measured with inductively coupled plasma mass spectrometry (ICP-MS: Pb, Cd) and high-performance liquid chromatography online with hydride generation ICP-MS (As-metabolites); concentrations were log2-transformed. All urinary markers were adjusted for specific gravity of urine. Two 24-h dietary recalls were conducted to estimate children's dietary intakes, including total fruit and vegetable consumption and vitamin C, zinc and fiber intake. Ordinary least square (OLS) and weighted quantile sum (WQS) regressions were used to estimate the association between metals and each OS marker as outcome. Metal exposure was generally low: median urinary As, Cd, Pb 9.6 μg/L, 0.06 μg/L and 1.9 μg/L, respectively. Median 8-isoprostane concentration was 1.1 and 8-OHdG 39.6 ng/mL. Log2-transformed urinary As concentrations were positively associated with 8-OHdG concentrations (10.90 [3.82, 17.97]) in covariate-adjusted OLS models which also took account of exposure to Cd and Pb. In WQS, a mixture index was also associated with higher 8-OHdG (8.71 [1.12, 16.3] for each 25% increase in index value), mostly driven by As exposure. There was little evidence of effect modification by dietary antioxidants. In sum, even at low-level, As exposure is associated with detectable oxidative damage to the DNA.

Autor

Kordas, Katarzyna
Roy, Aditi
Vahter, Marie
Ravenscroft, Julia
Peregalli, Fabiana
Martínez, Gabriela.
Queirolo, Elena I.

Fuente

Environmental Research v. 166, 2018. -- p. 507-515

Editor

Elsevier

Fecha

2018

Derechos

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PDF

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Inglés

Tipo

Artículo

Identificador

DOI: 10.1016/j.envres.2018.06.028

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Original Format

PDF
Fecha de agregación
May 8, 2019
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
Etiquetas
,
Citación
Kordas, Katarzyna, “Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed November 22, 2019, http://riquim.fq.edu.uy/items/show/5755.
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