Development of a methodology for the aimultaneous analysis of multiclass contaminants in milk.

A simple methodology for the simultaneous determination of 67 pesticides, 25 veterinary drugs, and aflatoxin M1 in raw milk
was developed and validated. After evaluating different combinations of sample preparation protocols, an extraction with acetonitrile:water (2:1) with QuEChERS citrate buffer salts and a combination of RP-C18 and anhydrous magnesium sulfate
for the dispersive clean-up, using gas and liquid chromatography couples to mass spectrometry for determination, was selected. Recovery percentages were between 70 and 120%, with relative standard deviations below 20% at 5, 20, and 50 μg kg−1. Aflatoxin M1 was recovered in the range 66 to 88% at 0.05, 0.1, and 0.5 μg kg−1 with relative standard deviation between 8 and 11%. The quantification limits for all the analytes with the exception of diclofenac were below their respective maximum residue
limits. The method was applied for the analysis of 20 commercial samples, some of which showed at least one contaminant below their maximum residue limits.

Información sobre Derechos de Autor

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La legislación uruguaya protege el derechode autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes (LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)