New perspectives into Gluconobacter-catalysed biotransformations

GLUCONOBACTER

BIOTRANSFORMACIONES

INGENIERIA GENETICA

BIOTECNOLOGÍA

QUIMICA VERDE

BIBLIOGRAFIA NACIONAL QUIMICA

2023

Different from other aerobic microorganisms that oxidise carbon sources to water and carbon dioxide, Gluco nobacter catalyses the incomplete oxidation of various substrates with regio- and stereoselectivity. This ability, as well as its capacity to release the resulting products into the reaction media, place Gluconobacter as a privileged member of a non-model microorganism class that may boost industrial biotechnology. Knowledge of new technologies applied to Gluconobacter has been piling up in recent years. Advancements in its genetic modifi cation, application of immobilisation tools and careful designs of the transformations, have improved pro ductivities and stabilities of Gluconobacter strains or enabled new bioconversions for the production of valuable marketable chemicals. In this work, the latest advancements applied to Gluconobacter-catalysed bio transformations are summarised with a special focus on recent available tools to improve them. From genetic and metabolic engineering to bioreactor design, the most recent works on the topic are analysed in depth to provide a comprehensive resource not only for scientists and technologists working on/with Gluconobacter, but for the general biotechnologist.

Biotechnology Advances, v.65, 2023. -- e108127

Elsevier

2023

Different from other aerobic microorganisms that oxidise carbon sources to water and carbon dioxide, Gluco nobacter catalyses the incomplete oxidation of various substrates with regio- and stereoselectivity. This ability, as well as its capacity to release the resulting products into the reaction media, place Gluconobacter as a privileged member of a non-model microorganism class that may boost industrial biotechnology. Knowledge of new technologies applied to Gluconobacter has been piling up in recent years. Advancements in its genetic modifi cation, application of immobilisation tools and careful designs of the transformations, have improved pro ductivities and stabilities of Gluconobacter strains or enabled new bioconversions for the production of valuable marketable chemicals. In this work, the latest advancements applied to Gluconobacter-catalysed bio transformations are summarised with a special focus on recent available tools to improve them. From genetic and metabolic engineering to bioreactor design, the most recent works on the topic are analysed in depth to provide a comprehensive resource not only for scientists and technologists working on/with Gluconobacter, but for the general biotechnologist.

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26 p.

Inglés

Artículo

10.1016/j.biotechadv.2023.108127

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