Residual infection of 15 Toxoplasma strains in the brain of rats fed cysts.
Dublin Core
Title
Residual infection of 15 Toxoplasma strains in the brain of rats fed cysts.
Subject
URUGUAY
PARASITOLOGIA
TOXOPLASMOSIS
TOXOPLASMA
BIBLIOGRAFIA NACIONAL QUIMICA
2001
Abstract
Thirty-seven groups of 4–32 Wistar rats were fed 2–103 cysts of 15 Toxoplasma strains. After 2 months, the rats were euthanized and their brains screened for Toxoplasma cysts and bioassayed in mice if negative. The brains of 323 of 411 rats (78.6%) were found to be infected 2 months after inoculation with Toxoplasma cysts. Two hundred cysts were necessary to infect nearly 90% of the rats. With lower doses, only 60% of the rats had residual brain infection. Brain cysts were formed only in 146 of 411 rats (35.5%). The numbers of cysts formed were in the order of tens to hundreds, only occasionally one or two thousands. The mean percentage of rats with brain cysts, and the number of cysts formed in rat brains by different inocula, increased with higher doses of cysts and then declined. This pattern is difficult to explain and similar results regarding the number of cysts formed have been published. In relation to the mean percentage of rats infected, there appears to be a plateau in infection with the higher inocula. Neither the number of rats with cysts in their brains nor the numbers of cysts formed were dependent on the Toxoplasma strain used, with the exception of one strain. Instead, individual variations were marked, and are presumably related to variations in the individual genetic resistance to Toxoplasma infection in the rat. The information gathered is considered a preliminary step for a rat model of immunity against acquired toxoplasmosis.
Creator
Freyre, A
Falcón, J
Correa, O
Méndez, J
González, M
Venzal, J.M
Source
Parasitology Research v. v.87, , 2001. -- p. 915-918
Publisher
Springer
Date
2001
Rights
Información sobre Derechos de Autor
(Por favor lea este aviso antes de abrir los documentos u objetos)
La legislación uruguaya protege el derecho de autor sobre toda creación literaria, científica o artística, tanto en lo que tiene que ver con sus derechos morales, como en lo referente a los derechos patrimoniales con sujeción a lo establecido por el derecho común y las siguientes leyes
(LEY 9.739 DE 17 DE DICIEMBRE DE 1937 SOBRE PROPIEDAD LITERARIA Y ARTISTICA CON LAS MODIFICACIONES INTRODUCIDAS POR LA LEY DE DERECHO DE AUTOR Y DERECHOS CONEXOS No. 17.616 DE 10 DE ENERO DE 2003, LEY 17.805 DE 26 DE AGOSTO DE 2004, LEY 18.046 DE 24 DE OCTUBRE DE 2006 LEY 18.046 DE 24 DE OCTUBRE DE 2006)
ADVERTENCIA - La consulta de este documento queda condicionada a la aceptación de las siguientes condiciones de uso: Este documento es únicamente para usos privados enmarcados en actividades de investigación y docencia. No se autoriza su reproducción con fines de lucro. Esta reserva de derechos afecta tanto los datos del documento como a sus contenidos. En la utilización o cita de partes debe indicarse el nombre de la persona autora.Format
PDF
Language
Inglés
Type
Artículo
Identifier
DOI: 10.1007/s004360100487
Coverage
Uruguay
Document Item Type Metadata
Original Format
PDF
