Lipid-Free Antigen B Subunits from Echinococcus granulosus: Oligomerization, Ligand Binding, and Membrane Interaction Properties : Lipid-Free Antigen B Subunits from Echinococcus granulosus
Dublin Core
Title
Lipid-Free Antigen B Subunits from Echinococcus granulosus: Oligomerization, Ligand Binding, and Membrane Interaction Properties : Lipid-Free Antigen B Subunits from Echinococcus granulosus
Subject
HIDATIDOSIS
ANTIGENO B
ECHINOCOCCUS GRANULOSUS
BIBLIOGRAFIA NACIONAL QUIMICA
2015
Abstract
The hydatid disease parasite Echinococcus granulosus has a restricted lipid metabolism, and needs to harvest essential lipids from the host. Antigen B (EgAgB), an abundant lipoprotein of the larval stage (hydatid cyst), is thought to be important in lipid storage and transport. It contains a wide variety of lipid classes, from highly hydrophobic compounds to phospholipids. Its protein component belongs to the cestode-specific Hydrophobic Ligand Binding Protein family, which includes five 8-kDa isoforms encoded by a multigene family (EgAgB1-EgAgB5). How lipid and protein components are assembled into EgAgB particles remains unknown. EgAgB apolipoproteins self-associate into large oligomers, but the functional contribution of lipids to oligomerization is uncertain. Furthermore, binding of fatty acids to some EgAgB subunits has been reported, but their ability to bind other lipids and transfer them to acceptor membranes has not been studied.
Creator
Silva Alvarez, Valeria
Franchini, Gisela R.
Pórfido, Jorge L.
Kennedy, Malcolm W.
Córsico, Betina
Source
PLoS Neglected Tropical Diseases v. 9, no. 3, 2015. --e0003552, 23
Publisher
Public Library of Science, San Francisco
Format
PDF
Language
Inglés
Type
Artículo
Identifier
DOI: 10.1371/journal.pntd.0003552
