Evaluation of different PAMAM dendrimers as molecular vehicle of 1, 2, 4-triazine N-oxide derivative with potential antitumors activity
Dublin Core
Title
Evaluation of different PAMAM dendrimers as molecular vehicle of 1, 2, 4-triazine N-oxide derivative with potential antitumors activity
Subject
ANTINEOPLASICOS
ESTABILIDAD QUIMICA
BIBLIOGRAFIA NACIONAL QUIMICA
2013
Abstract
The interaction between a 1,2,4-triazine N-oxide derivative, that holds potential antitumor activity under hypoxic conditions, and diverse polyamidoamine (PAMAM) dendrimers were investigated with the purpose of select the most appropriate macromolecule to act as potential molecular carrier of this active compound. The results shows that dendrimers with amine terminal groups (PAMAM-AT G = 3) and dendrimers with carboxylate terminal groups (PAMAM-CT G2.5 and G4.5) produces triazine derivative hydrolysis, even in buffered medium, and are not suitable as carriers. In contrast, dendrimers with neutral end groups (PAMAM-OHT) shows stable association with the active compound, making this dendrimer a possible medium for triazine carriage.
Creator
Dib, Nahir
Fernández, Luciana
González, Mercedes
Cerecetto, Hugo
Durantini, Edgardo
Otero, Luis
Santo, Marisa
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