Immune profiling of breast milk from mothers with treated celiac disease
Dublin Core
Title
Immune profiling of breast milk from mothers with treated celiac disease
Subject
ENFERMEDAD CELIACA
LECHE MATERNA
PERFIL INMUNE
BIBLIOGRAFIA NACIONAL QUIMICA
2020
Abstract
Background The protective effect of breastfeeding on celiac disease (CD) onset is controversial. We studied a wide range of milk components in milk produced by celiac mothers following long-term gluten-free diet (GFD) in comparison to milk produced by healthy mothers. Methods Breast-milk samples from celiac (n = 33) and healthy (n = 41) mothers were obtained during the first year of lactation. A panel of bioactive components was analyzed by enzyme-linked immunosorbent assay in the aqueous fraction. We studied molecules involved in defenses, immunoregulation, and strengthening of the gut–epithelial barrier. Results During late lactation (from 6 to 12 months after delivery), the content of total immunoglobulin A (IgA) and IgM was significantly lower in the milk produced by celiac patients. Nevertheless, gliadin (GFD)-specific IgA relative contribution was higher in this group, in contrast to tetanus toxoid-specific antibodies. The balance between pro-inflammatory and anti-inflammatory molecules was different. While interleukin-6, tumor necrosis factor-α, and monocyte chemoattractant protein-1 were most frequently found in samples from celiac mothers, soluble Toll-like receptor-2 prevalence was lower. Conclusions We describe differences between the innate and adaptive immune profile of milk produced by celiac and healthy mothers. These results might explain previous controversial reports about breastfeeding and CD protection.
Creator
Villamil, Emilia
Rodríguez-Camejo, Claudio
Puyol, Arturo
Fazio, Laura
Colistro, Valentina
Hernández, Ana
Source
Pediatric Research 2020.-- p. 1-9
Publisher
Springer
Date
2020
Rights
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Format
PDF
Language
Inglés
Type
Artículo
Identifier
DOI: 10.1038/s41390-020-0901-y
Document Item Type Metadata
Original Format
PDF
