Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs
Dublin Core
Title
Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs
Subject
TRYPANOSOMA CRUZI
TUBERCULOSIS
COMPUESTOS HETEROCICLICOS
QUINOXALINA
BIBLIOGRAFIA NACIONAL QUIMICA
2009
Abstract
Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1,4-di-N-oxide derivatives have been prepared and tested against M. tuberculosis and T. cruzi. Carboxylic acid quinoxaline 1,4-di-N-oxides (CAQDOs) 5 and 17 showed MIC values on the same order as the reference antituberculosis drug, rifampicin. Meanwhile, CAQDOs 12 and 22 presented IC50 values in the same order as the anti-chagasic drug, nifurtimox.
Creator
Ancizu, Saioa
Moreno, Elsa
Torres, Enrique
Burguete, Asunción
Pérez-Silanes, Silvia
Benítez, Diego
Villar, Raquel
Solano, Beatriz
Marín, Adoración
Aldana, Ignacio
Cerecetto, Hugo
González Hormaizteguy, María Mercedes
Monge, Antonio
Source
Molecules (Basel, Switzerland) v.14, no. 6, 2009. -- p.2256-2272
Publisher
MDPI
Date
2009
Type
Artículo
Identifier
doi: 10.3390/molecules14062256.
Document Item Type Metadata
Original Format
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