Prenatal exposure to vaporized high-potency cannabis affects hippocampal synaptic remodeling and efficacy, axonal excitability, and memory in offspring

Dublin Core

Title

Prenatal exposure to vaporized high-potency cannabis affects hippocampal synaptic remodeling and efficacy, axonal excitability, and memory in offspring

Subject

CANNABIS SATIVA
EMBARAZO
CANNABINOIDES
NEURODESARROLLO
SISTEMA NERVIOSO
DESARROLLO EMBRIONARIO
TRASTORNOS RELACIONADOS CON SUSTANCIAS
MEMORIA
EXCITABILIDAD NEURONAL
FUNCION SINAPTICA
BIBLIOGRAFIA NACIONAL QUIMICA
2025

Abstract

Cannabis use during pregnancy has recently become an important concern due to its increasing trend and association with neurodevelopmental alterations of exposed children. Although inhalation is the primary route of cannabis consumption in humans, few studies replicated this route in preclinical models of prenatal exposure. This study aimed to analyze the effects of chronic prenatal exposure to vaporized cannabis (PEVC) on hippocampal neurodevelopment, functionality, and learning and memory processes. Using a commercially available high-potency cannabis strain (THC 14.7%), pregnant rats were exposed to cannabis vapor from gestational day 8 to 21. A combination of primary hippocampal cultures, electrophysiological studies in slices, and behavioral tests was employed to assess the impact of PEVC. We found that PEVC induced presynaptic remodeling of hippocampal neurons in offspring under both basal and activity-dependent conditions by increasing synaptic vGlut1 abundance and the total recycling pool of synaptic vesicles. Chronic PEVC also induced a downregulation of CB1R at glutamatergic and GABAergic synapses. Additionally, an increase in axonal recruitment and synaptic efficacy was observed at hippocampal CA1 synapses of juvenile offspring. Moreover, long-lasting cognitive impairments were identified during adolescence, including deficits in spatial memory in male and female offspring. In summary, these findings demonstrate that exposure to high-potency cannabis vapor during pregnancy leads to significant changes in synaptic remodeling and efficacy, axonal recruitment, and long-term cognitive consequences in offspring.

Creator

Cairus, Andrea
Brizolara, Facundo
Kunizawa, Héctor
Clouzet, Vanina
Gonzalez, Giuliana
Alsina-Llanes, Marcela
Dellepiane, Lucía
Fernández, Santiago
García-Carnelli, Carlos
Umpierrez, Eleuterio
Borde Bebeacua, Michel
Prieto, José Pedro
Vitureira Serpa, Nathalia

Source

Journal of Neurochemistry, v. 169, n°7, 2025. -- e70153

Publisher

Wiley

Date

2025

Rights

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Format

PDF

Extent

15 p.

Language

Inglés

Type

Artículo

Identifier

10.1111/jnc.70153

Document Item Type Metadata

Original Format

PDF
Date Added
October 14, 2025
Collection
Bibliografía Nacional Química
Item Type
Document
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Citation
Cairus, Andrea et al., “Prenatal exposure to vaporized high-potency cannabis affects hippocampal synaptic remodeling and efficacy, axonal excitability, and memory in offspring,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed November 17, 2025, https://riquim.fq.edu.uy/items/show/6997.