TRASTORNOS NEURODEGENERATIVOS

HIBRIDOS DE TIAZOL-NITRONA

ESTRES OXIDATIVO

APOPTOSIS

CASPASA-3

SALUD PUBLICA

NEUROPROTECCION

BIBLIOGRAFIA NACIONAL QUIMICA

2025

Neurodegenerative diseases affect millions worldwide, posing significant challenges to public health. Oxidative stress and increased caspase-3 activity are key features in the development and progression of neurological disorders leading to neuronal damage and cell loss. As part of our ongoing efforts to identify new molecules with enhanced neuroprotective potential, we have synthesized six novel thiazole-nitrone hybrid compounds, designed as dual-action antiapoptotic and antioxidant agents. The nitrone moiety is known for its spin-trapping ability, which confers antioxidant and neuroprotective properties, while thiazole-containing compounds have been described as antioxidants and potent caspase-3 inhibitors. Our findings demonstrate that these hybrid compounds effectively reduce intracellular reactive oxygen species (ROS) levels and mitigate apoptosis rates in a hippocampal cell line by decreasing active caspase-3 activity, confirming their antioxidant and antiapoptotic properties. Notably, two of the six evaluated compounds exhibited the most promising neuroprotective profiles, including favorable blood-brain barrier permeability. Altogether, these results position the identified molecules as excellent candidates for further structure-based optimization, contributing to the development of more efficient therapeutic strategies against neurodegenerative disorders.

Results in Chemistry, v. 16, 2025. -- e102414

Elsevier

2025

PDF

8 p.

Inglés

Artículo

10.1016/j.rechem.2025.102414

PDF