In Vitro Bioaccessibility of Extractable Compounds from Tannat Grape Skin Possessing Health Promoting Properties with Potential to Reduce the Risk of Diabetes.

Dublin Core

Título

In Vitro Bioaccessibility of Extractable Compounds from Tannat Grape Skin Possessing Health Promoting Properties with Potential to Reduce the Risk of Diabetes.

Tema

ANTIINFLAMATORIOS
ANTIOXIDANTES
AMILASA
DIABETES
GLUCOSIDASA
ENZIMAS
UVA TANNAT
TRANSPORTADORES DE GLUCOSA
BIBLIOGRAFIA NACIONAL QUIMICA
2020

Abstract

Diabetes pathogenesis encompasses oxidative stress, inflammation, insulin malfunctioning and partial or total insulin secretion impairment, which leads to a constant hyperglycemia. Polyphenols are known to possess bioactive properties, being Tannat grape skin a natural and sustainable source of these compounds. The present study aimed to find out the bioaccessibility of health-promoting molecules composing a multifunctional extract from Tannat grape skin obtained under hydro-alcoholic-acid conditions. The identification of phenolic compounds in the samples was performed by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Subsequently, the samples were in vitro digested mimicking the human oral gastrointestinal conditions and the bioactivity of the digest (antioxidant, anti-inflammatory and modulation of glucose metabolism) was assessed. E ect on glucose metabolism was estimated by measuring carbohydrases activity and the functionality of glucose transporters of small intestine cells in presence and absence of the digested extract. Flavonoids, phenolic acids and phenolic alcohols were the major phenol compounds detected in the extract. The bioaccessible compounds protected the intestinal cells and macrophages against the induced formation of reactive oxygen species (ROS) and nitric oxide (NO). In addition, glucose transporters were inhibited by the digested extract. In conclusion, the bioaccessible compounds of the extract, including phenols, modulated key biochemical events involved in the pathogenesis of diabetes such as oxidative stress, inflammation and glucose absorption. The extract was e ective under prevention with co-administration conditions supporting its potential for either reducing the risk or treating this disease.

Autor

Fernández Fernández, Adriana Maite
Iriondo DeHond, Amaia
Nardin, Tiziana
Larcher, Roberto
Dellacassa, Eduardo
Medrano Fernández, Alejandra
Del Castillo, María Dolores

Fuente

Foods v. 9, 2020. -- p. 1-14.--e1575

Editor

MDPI

Fecha

2020

Derechos

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Formato

Pdf

Idioma

Inglés

Tipo

Artículo

Identificador

doi:10.3390/foods9111575

Document Item Type Metadata

Original Format

Pdf
Fecha de agregación
April 6, 2021
Colección
Bibliografía Nacional Química
Tipo de Elemento
Document
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Citación
Fernández Fernández, Adriana Maite, “In Vitro Bioaccessibility of Extractable Compounds from Tannat Grape Skin Possessing Health Promoting Properties with Potential to Reduce the Risk of Diabetes.,” RIQUIM - Repositorio Institucional de la Facultad de Química - UdelaR, accessed December 1, 2021, http://riquim.fq.edu.uy/items/show/6220.
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